Does anyone know if you can take Avelox and Prednisone together?

No, not at all. Do NOT take together. Concomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture ociated with fluoroquinolone treatment. The mechanism is unknown. Tendinitis and tendon rupture have most frequently involved the Achilles tendon, although cases involving the rotator cuff (the shoulder), the hand, the biceps, and the thumb have also been reported. Some have required surgical repair or resulted in prolonged disability. Tendon rupture can occur during or up to several months after completion of fluoroquinolone therapy.